RESET PLATFORM
The Junevity RESET Platform develops novel therapeutics to restore gene networks with human disease data, machine learning and siRNA.
Transcriptional dysregulation drives disease
PROBLEM
Diseases related to longevity and aging see profound gene dysregulation, which is often overlooked in drug discovery due to its complexity.
Restore gene networks
SOLUTION
Dr. Janine Sengstack was the first to show that repressing a single transcription can restpre gene expression to healthy state in her work at UCSF (PNAS, 2026).
Junevity builds on this approach. We identify genetically-linked pathways that become overactive with age and disease. Then, we develop safe siRNA therapeutics to restore these pathways to a healthy state and reverse disease.
This approach unlocks new therapeutics for diseases related to longevity and aging.
RESET Platform
HOW WE DO IT
RESET is a therapeutic discovery platform combining human omics, genetic linkages, machine learning and siRNA.
Our first-of-its-kind platform enables safe siRNA therapeutics supported by genetic evidence.
